sMallviLLe seAson 5 ePisode 2

Lex comes to Belle Reve to visit his father, who is locked up in a cell and kept in a straight jacket. Elsewhere, a heavily guarded trio of prisoners are being escorted away – a big guy and a pair of bald twins. The big guy, Lee, bumps into Lex and somehow manages to release his electro-manacles. Seconds later he breaks free, displaying the ability to channel electricity. He frees the twins who can touch their hands and fire force projections. Together the three of them make their escape and head for…Smallville.

Jonathan and a non-powered Clark are helping their neighbors put up a new barn and Chloe pays a visit to commiserate over Clark’s new found mortality. Chloe wonders if he’s avoiding his destiny but Clark is happy, and gets together with Lana. Clark heads back to the Kent farm to get some nails and Lana goes with him, but not before Lex arrives to have a heart-to-heart with Clark. Lex thinks they’ve been given a second chance and they both dance around rebuilding their friendship before Clark heads out with Lana. En route, they decide to focus on the future and ignore their respective pasts. Clark and Lana get to his loft and go into a makeout session, but not before confessing they’re both virgins. They’re interrupted by the three prisoners, and the twins immobilize Clark to the roof. The leader announces they want…Clark.

The escapees take Clark and Lana into the partially rebuilt Clark household, while Chloe goes to the caves and the secret chamber with the key pedestal. The chamber is dead and Lex arrives to confront her about how she ended up in Alaska, and taunts her with the knowledge of Lana and Clark together. Chloe mentions the disappearance of the spaceship and Lex denies knowing about it, and Chloe threatens she’ll investigate if he doesn’t drop it.

The escapees reveal they want Clark to go into Level 3, a top secret research facility at LuthorCorp. The prisoners were in Level 3 and were subjected to green kryptonite injections – now they’re addicted. The place is guarded against them, but they think Clark can get in. Then Martha and Jonathan show up and Clark tries to get rid of them, without much success. They get taken hostage and Clark has no choice but to head for the LuthorCorp facility and get the serum in two hours.

Clark and Chloe manage to get inside, thanks to Chloe’s skills, while Sheriff Adams drops by. Lee holds Martha hostage to ensure their good behavior. Sheriff Adams wonders about Martha’s absence and decides to hang around for some coffee. Meanwhile Clark is climbing through the air vents under Chloe’s guidance, but triggers a lockdown protocol and ends up in Level 3. Sheriff Adams is getting ready to leave when she notices Lee’s cigarettes and figures out the prisoners are there. She alerts the police but Lee fries her and then Jonathan drops him. Lana slugs the twins and manages to pin one to the wall by his hand with a nail gun. The twins are psychically linked but they manage to knock Lana out and Lee punches out Jonathan. The police arrive but the twins seal off the farm with a force barrier, but they’re surrounded.

Clark pokes around Level 3 and lets Chloe in, then figures out they can bypass security using Lex’s fingerprint from the flashlight he was using in the cave and that Chloe kept. The twins are starting to weaken but Lee calls them, demanding the serum, just as they open the vault. However, there’s a laser barrier and Clark is injured, with no way to get by. Clark drives back to the farm and asks Adams to withdraw her men. She reluctantly agrees and Clark calls in so they’ll let him in. Clark has a suitcase and gives it to Lee, but when he opens it there’s one of Chloe’s tear gas grenades inside. Clark leaps aside and Lee accidentally nails the twins, then Clark cuts the power he’s drawing on and punches him out.

Chloe shows up to reveal that someone was watching them on the cameras, as they broke into the lab. Clark goes to confront Lex, who is watching the video. Clark slugs him and then hits him again. Lex denies it. Clark figures that Lex helped the prisoners get free and Lex punches him back – he’s confused when Clark bleeds. Clark meets up with Lana later at her apartment to commiserate and the two end up together.

seX educaTion in IslaM

ada arTikel bagUs niH dapeT nGopi siH taPi ga Papa kan? niH baCa ya moGa-moGa biSa leBih terBUka lagi ttg iSlam

Q: At what age should a child be taught sex education?

Gumbi : As we all know, there is nothing which Islam has not taught its followers. Sex education in Islam is taught theoretically and not practically. If a child is being taught sex education it is not permissible for his teacher to come into body contact with him during the period of study. As long as a person has reached the age of puberty, it is not permissible for him/her to see the thigh of another person. However, sex education can be taught properly. When we look at the book of Buhari, a hadith from the Prophet (PBUH) shows where he (the Prophet) was teaching his companions how to perform purification bath, he said, “if he sits in between her (thighs) and exhausts her, then a purification bath becomes compulsory.” Here, he only made a statement which explains how intercourse may take place, but he did not say come and sit here let me demonstrate how it is done. Therefore when teaching, there is no harm in explaining how it is done. There is even no harm in drawing on the board, but not when the teacher and his students come in contact. We have books in Islam, which explain the purification bath, what spoils ablution; some of these things explains how the sperm or semen is emitted.

Q: Still, at what age should a child know about sexual intercourse?

Gumbi: In modern times, a child of primary school, say age seven, should start knowing these things, before he/she becomes fully mature.

Q: Is it proper for children to start knowing about sexual oriented vices like homosexuality at such age?

Gumbi: Yes, it is in Islamic books of jurisprudence and history. It has shown that homosexuality and their likes exist. Children should be taught about this, likewise the punishment for it. If you go to our settlements in Northern Nigeria, remote areas where we grew up, you will find young children learning about these things. They learn about them and their punishments, so that by the time they grow up and mature, they will know how to deal with such cases. They should know that it is forbidden.

Q: What is the Islamic perspective on masturbation. Is it proper for young children to learn it?

Gumbi: Whatever it is that Allah has ordered mankind to adhere to and forbid them from, there is no harm in young children knowing about them. They should know them thoroughly and then learn their virtues and vices. All that matters is that they should not see them being done practically, so that they will not attempt doing it.

Q: What is the Islamic view on contraception and what effect does it have on children knowing about them?

Gumbi: Teaching children about contraceptives such as condom, is like encouraging them to go and have sex, because in the Hausa culture, what makes one to migrate to another area is the issue of pregnating a woman out of wedlock. With the introduction of condoms, these people of shameful character have found an avenue to do so as they wish. Therefore it has become necessary for children to know that these things have negative effects, even if they have advantages. They should know that it should be used when lawfully married.

Q: Is it permissible for young children to know the intensity of sexual arousement, like where to touch, how a partner should react, and other heated sensations, which cannot be mentioned here?

Gumbi: If it is all in explanation, there is no fault. In Abu Hanifah’s school of thought, he said, there is no harm for a person seeking marriage to smell the lady he intends marrying and vice versa and there is also no harm for them looking at each other properly, because they are expected to be life partners. there is no harm in children knowing all these things. All that matters is that there should be no practicals. As a young man growing up, there was a time my Mallam [teacher] was teaching me, you know how raw Sokoto Hausa is [the local language], he said penis in Hausa, he said virgina in Hausa and then was explaining how one enters the other then I laughed, he cautioned me not to laugh and said that “fiqhu cannot be taught without explanation.” Even the Prophet (PBUH) was asked by a woman as is narrated by a Hadith reported by Aisha. The woman asked what the Islamic injunction of a woman who sees what a man sees, she was referring to wet dreams, because a woman can have a wet dream just as a man does. Before the Prophet (PBUH) was able to answer, Aisha said to the woman “why are you asking such a question? do you want to embarrass us in front of the Prophet?” the Prophet then said there is no shame in knowing one’s religion. Ask everything that you do not understand.

Q: In this part of the country, the mention of sexuality education makes people jittery due to lack of the knowledge of fiqh. Or is it the normal culture here?

Gumbi: People here like to wear the garb of ignorance whereas they know what is true. Somehow they are 100 years backwards. Even what they read in the fiqh books have not fully been comprehended. When in the past sexuality education was not taught, it led people to pregnanting women out of wedlock, which is very shameful. Islam is not against theoretical sex education. It only frowns at the practical aspect. Sex is a natural thing. no animal is taught it. it happens naturally.

Q: What is the Islamic view on abortion?

Gumbi: Abortion in Islam is haram (forbidden). However, there is the permissible abortion where a married woman is concerned, where it is discovered that if a child would become a nuisance to people if it was born with some deformity or something of that nature. Now, questions where thrown to scholars, where it was agreed that abortion is haram, except in a case where the foetus has not yet matured to become a living being.

Q: Still on sex education, some have the view that sex education should be left as parent’s responsibility. What is your view?

Gumbi: There are schools where human mannequins are brought in front of the class and these mannequins are used to demonstrate the sexual act. Muslims have frowned at such demonstrations because children would practice it when it is practically shown to them. However, it has to be taught because children will mature and like we have been stressing, it should be taught theoretically, so that when these children mature, they will know what to do in the light of difficult circumstances and situations that arise in relation to sexual intercourse.

SmaLLviLLe sEaSoN 5 ePisode 1

The stone spins through the aid and crashes into the snow, and the ground shakes. A huge crystalline fortress emerges from the ground. Clark enters and one small crystal floats up to him. Jor-El addresses him and warns him that a new journey is beginning.At the crash site in Smallville, Lana looks on as a burst of light flares from the ship and two figures, a man and woman, emerge. They confront Lana but before she can do anything police arrive. Lana limps off as the newcomers use superpowers like Clark’s to take out the police. Afterward they say they must find Kal-El, and they have tattoos similar to the one Lana had on her.

Lois arrives at the Kent house which has been hit by a meteor, and helps Jonathan find an injured Martha and take her to the hospital. In the Indian cave, Lex wakes up and looks for Chloe, but only finds her phone. He also finds the secret chamber and the octagon key. He then turns and spots the two newcomers, who use x-ray vision to determine Lex has the key and then take it. They want to know if he’s Kal-El but determine he isn’t and toss him casually aside before superspeeding away.

Chloe wakes up in the Arctic as well and spots the fortress. Clark is speaking with Jor-El, who reveals the geography of Krypton has been replicated for his training. Jor-El warns that a dark force from Krypton poses a danger to everyone, and Clark must study to learn what he needs to save the planet. Chloe comes in and sees Clark, but a wind springs up and quickly freezes her as she calls out for Clark. Clark hears her and goes to her but Jor-El warns he cannot stop his studies. Jor-El agrees but warns Clark must return before the yellow sun sets or the consequences will be grave. Chloe wakes up enough to let Clark know she knows about his superpowers and he superspeed-runs her to a nearby hospital.

Lex is driving along and finds a shocked Lana, who warns him about the aliens and reveals they came out of a spaceship before collapsing. Chloe and Clark discuss how she knew about his powers, and he reveals he’s an alien. Clark hears a TV newscast about Smallville and a shot of his parents, and Chloe tells him he needs to go for them, which he does.

Lana wakes up at Lex’s mansion and finds Lionel drawing symbols on the floor. A seemingly blind Lionel speaks of the “disciples of Zod” and warns they can only be stopped by their home planet, which is poison. He points Lana toward the vault containing kryptonite. Martha wakes up at the hospital and Lois shows up, but they’re interrupted by explosions and the two aliens step in and demand Kal-El and know Jonathan knows of him. Lois intervenes and gets attacked, but Lana arrives and tells them Kal-El is at the mansion. They release Lois, release Lana, and leave.

Clark arrives at his house where Lex brings him up to speed then asks about Chloe. He claims that Clark was at the cave when the meteors hit but Clark denies it despite Lex’s asking for honesty. Afterward Clark meets Lois at the hospital and she warns him they were looking for Kal-El and went to the manor. At the manor, Lana leads them to the vault where they collapse but manage to stagger out and seal the door. They knock out Lana but Clark arrives and announces he’s Kal-El. They reveal they are the last survivors of Krypton and want him to join them in conquering the world. Clark refuses and the woman throws a bracelet-like device that creates some kind of portal to some kind of prison-dimension – the other one then knocks him into it but Clark manages to grab hold but is still slowly pulled in. When they turn away he manages to pull himself clear and throw them in. The portal-prison then turns into a rectangle and flies out the window, while Clark goes to help Lana as the sun sets. He spots the key but when he cuts his finger on glass he realizes he now powerless.

Martha and Jonathan return to the farm and Clark reveals he’s lost his powers, but that he’s happy he normal. Lex tracks Chloe down to the hospital in the Yukon and comes to take him home. Clark goes to visit Lana, who has received a message from Lex saying he covered up the deaths of Jason and his mother. Lana admits she meant it when she told him she loved him, and Clark reciprocates the feelings. Lana tells him about the spaceship and he goes to see it – it’s gone. At a LuthorCorp facility, the spaceship is in a secret hangar and is leaking a black oil. The oil streams away from the spaceship, and forms into a humanoid figure.

 

 

Terapi Gen untuk Penyakit Paru-Paru

Terapi Gen untuk Penyakit Paru-Paru

Cystic fibrosis (CF) dan defisiensi α1-antitrypsin adalah penyakit yang dihubungkan dengan kerusakan gen tunggal dan menggambarkan secara rasional untuk terapi gen dengan menggantikan yang tak sempurna. Kerusakan sistem pernafasan kronik seperti CPOD, asma, atau penyakit paru intersisial. Kondisi inflamasi kronik seperti munculnya ketidakseimbangan antara mekanisme perlindungan dan penghancuran. Terapi gen dapat sangat berguna untuk memulihkan keseimbangan dengan jangka waktu yang pendek. Vektor viral dan nonviral digunakan untuk transfer gen ke jaringan paru. Vektor yang digunakan untuk transfer gen ke paru adalah replication-deficient adenoviruses dan liposom sintetik/ kompleks DNA, tetapi yang paling sukses dengan menggunakan adeno-associated virus (AAV) dan lentivirus. Liposom menghasilkan respon imun yang signifikan, kemungkinan pencetusnya sekuens CpG. Untuk memperbaiki sistem transfer nonviral termasuk penggunaan glycoconjugates dan polyplexes, target kompleks reseptor enzim-serpin, polyethylenemine dan formulasi nanopartikel serta motif CpG pada plasmidnya. Kombinasi dari sediaan liposom seperti dexamethasone, spermine dan dioleoylphosphatidyletanolamine. Keuntungan dari adenovector adalah efisiensi yang sangat baik pada transfer gen, yang telah di demonstrasikan pada banyak sistem. Efisiensi transfer terbatas pada usahanya seperti penggabungan reseptor sisi utama pada permukaan basolateral sel epitel. Vektor AAV telah menunjukkan ekspresi spesifitas infeksi yang luas dan panjang pada jaringan paru. Perkembangan yang baik adalah penggunaan aerosol pada manusia. Seperti yang telah digambarkan untuk adenovirus beberapa perkembangan yang terlibat beberapa isoform manusia AAV (mis, AAV2, AAV5, dan AAV6), dengan AAV5 lebih efisien diambil oleh sel epitel dibandingkan AAV2. Ada beberapa penyebab pada kegagalan CF: (1) sistem vektor ideal belum dikembangkan. (2) Jawaban dari pertanyaan bagian sel paru adalah target terbaik untuk terapi gen CF masih harus dijelaskan. (3) Penempatan gen CFTR pada saluran udara kemungkinan tidak tercukupi untuk semua kerusakan fungsi pada pasien CF.

Nama               :   Nur Ma’rifah Azzumar

NIM                 :   O1A005018

Email                :   oRang3_tiGg3R@yahoo.com

Blog                 :   http://nurmarifah.wordpress.com/

 

 

gaPteK

y… munGkin itu kali salah satu siFat eike gaptek, alias gagap teknologi. gila masa jaman daH seRba canGGih kaya ginI baru bisa biKin blog, bayangkan….

untunGlah ikut mata kuliah BioteknoLogi Farmasi jadi sudaH mulai beRkuRang gaPtek q

Hello world!

Welcome to WordPress.com. This is your first post. Edit or delete it and start blogging!